Rhodes DR, Yu J, Shanker K, Deshpande N, Varambally R, Ghosh D, et al. CDKN3 mRNA as a biomarker for survival and therapeutic target in cervical cancer. 2007;45(4):938–47. 2018;7:e41604. In our current study, Oncomine analysis showed that CDKN3 was significantly elevated in anaplastic oligoastrocytoma, leukaemia, HCC, and sarcoma. Previous studies have focussed on the pathogenesis of liver cirrhosis developing into HCC, but the molecular mechanism remains unclear. Previous studies have focussed on the pathogenesis of liver cirrhosis developing into HCC, but the molecular mechanism remains unclear. Hepatology. Front Genet. Biomed Pharmacother. 2011;17(Suppl 2):S34–43. Squamous cell lung carcinoma vs. normal tissues (Hou PLoS One, 2010 [46]); 4. Khosa F, Khan AN, Eisenberg RL. Relationships between CDKN3, CYP2C9 and LCAT, and their expression in different types of liver tissues. Giordano TJ, Thomas DG, Kuick R, Lizyness M, Misek DE, Smith AL, et al. DEGs identified in the four microarray datasets (382 in GSE17548, 870 in GSE54236, 1094 in GSE63898, and 210 in GSE89377) were screened after the chip results were normalised. Bruix J, Sherman M. Management of hepatocellular carcinoma: An update. PubMed Central  CAS  This type of biopsy helps doctors determine whether the tumor is actually invading the portal vein. By integrating multiple microarray gene expression profiles, three key genes (LCAT, CYP2C9, and CDKN3) were identified that appear to be important for the conversion of liver cirrhosis into HCC. Nakamura A, Osonoi T, Terauchi Y. 2008;359(4):378–90. Article  Early screening and preventive treatment for patients with HCC can effectively prolong the 5-year survival rate [25]. The results showed that changes in CDKN3 expression mainly affected pathways related to HCC, such as the cell cycle, DNA replication, oocyte meiosis and mismatch repair. Abdom Imaging. Cell Mol Biol. LCAT encodes an extracellular cholesterol esterase, lecithin-cholesterol acyltransferase, and cholesterol esterification is essential for cholesterol transport [25]. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. PubMed  Chin Clin Oncol. CT and MR imaging diagnosis and staging of hepatocellular carcinoma: part I. Mechanistic studies of cyclin-dependent kinase inhibitor 3 (CDKN3) in colorectal cancer. Each semester Holyoke Community College recognizes superior scholarship through the Dean's List. STRING database screening and PPI network construction were performed, and visualization was carried out using Cytoscape software (Fig. 1999;27(1):29–34. 2017;25(9):1431–40. 2a–c), demonstrating a specific interaction between hub genes. This is a time for us to grow professionally, to bring the best of ourselves to share with each other, to encounter new and innovative ideas, and to renew our conviction that together we are more than the sum of our parts. XY, JFL and CHJ collected the literature. Adrenal cortex carcinoma vs. normal tissues (Giordano Am J Pathol, 2003 [45]); 2. National Early Detection and Treatment Project for Upper Digestive Tract in Rural Area in China (NO. 2019;71(2):265–73. Oncol Res. In those with indeterminate nodules on imaging criteria or with non-cirrhotic livers, a tissue diagnosis (biopsy) is needed to establish the diagnosis. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. d–f Expression of CDKN3, CYP2C9 and LCAT under normal, cirrhotic, hepatocellular carcinoma and hepatic dysplasia conditions in the Wurmbach liver dataset, Overall survival analyses of hub genes (CDKN3, CYP2C9 and LCAT) performed using the Kaplan–Meier Plotter online platform, p < 0.05 was considered statistically significant, Association between the expression of CDKN3 and tumour grade (a), hepatitis virus infection status (b), satellites (c), and vascular invasion (d) in the Wurmbach liver dataset. Serum IGF-1, IGF-2 and IGFBP-3 as parameters in the assessment of liver dysfunction in patients with hepatic cirrhosis and in the diagnosis of hepatocellular carcinoma. Risk factors for liver cancer include hepatitis B and C infection, cirrhosis, and alcohol intake; 80 to 90% of HCC patients have cirrhosis, which is the most important risk factor [22, 23]. https://doi.org/10.1016/j.jhep.2018.03.019, https://doi.org/10.1007/978-3-319-92216-4_6. Zubiete-Franco I, Garcia-Rodriguez JL, Lopitz-Otsoa F, Serrano-Macia M, Simon J, Fernandez-Tussy P, et al. Google Scholar. However, the mechanism by which cirrhosis develops into liver cancer is still unclear. Diagnostic value of HSP70, glypican 3, and glutamine synthetase in hepatocellular nodules in cirrhosis. http://bioinformatics.psb.ugent.be/webtools/Venn/, https://doi.org/10.1371/journal.pone.0010312, http://creativecommons.org/licenses/by/4.0/, http://creativecommons.org/publicdomain/zero/1.0/, https://doi.org/10.1186/s12967-020-02229-8. 2015;10(9):e0137397. 2011;44(3):291–9. Article  PubMed Central  In many liver diseases, there are no significant differences in the incidence of liver cancer between cirrhotic and non-cirrhotic states. Relationship between urinary sodium excretion and pioglitazone-induced edema. Hypervascular liver lesions on MRI. Louet M, Labbe CM, Fagnen C, Aono CM, Homem-de-Mello P, Villoutreix BO, et al. AJR Am J Roentgenol. Global cancer statistics, 2012. Dig Liver Dis. Among the DEGs, three potential hub genes (CDKN3, CYP2C9 and LCAT) were obtained using the MCODE plug-in of Cytoscape. MCODE plugin used to find the top hub genes, the most closely connected module was identified (Fig.

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